Gene information
Official symbol THBD
Official full name thrombomodulin
Gene type protein-coding gene
Chromosome20p11.21
Alias symbolCD141; THRM; BDCA-3
Gene familyCD molecules; C-type lectin domain containing
Resources
Entrez Gene 7056
HGNC HGNC:11784
Ensembl ENSG00000178726
Vega OTTHUMG00000032053
UCSC uc002wss.4
GO terms: 51 records
GO Description Category LogP Number of genes Detail
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0005509 calcium ion binding GO Molecular Functions -14.7764642 80 More
GO:0005774 vacuolar membrane GO Cellular Components -1.32038132 10 More
GO:0007565 female pregnancy GO Biological Processes -18.4002911 25 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0009314 response to radiation GO Biological Processes -9.77450393 26 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0010212 response to ionizing radiation GO Biological Processes -3.25353717 8 More
GO:0010543 regulation of platelet activation GO Biological Processes -12.2843439 12 More
GO:0010544 negative regulation of platelet activation GO Biological Processes -8.56314160 7 More
GO:0014074 response to purine-containing compound GO Biological Processes -9.77915279 26 More
GO:0016485 protein processing GO Biological Processes -23.0561441 30 More
GO:0030193 regulation of blood coagulation GO Biological Processes -37.6853179 30 More
GO:0030194 positive regulation of blood coagulation GO Biological Processes -18.9359595 14 More
GO:0030195 negative regulation of blood coagulation GO Biological Processes -29.1940441 22 More
GO:0031638 zymogen activation GO Biological Processes -13.0866363 13 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0044703 multi-organism reproductive process GO Biological Processes -20.5752550 28 More
GO:0044706 multi-multicellular organism process GO Biological Processes -20.0155761 28 More
GO:0046683 response to organophosphorus GO Biological Processes -8.57801626 23 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050818 regulation of coagulation GO Biological Processes -40.0839917 32 More
GO:0050819 negative regulation of coagulation GO Biological Processes -31.8350192 24 More
GO:0050820 positive regulation of coagulation GO Biological Processes -18.6547980 14 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050866 negative regulation of cell activation GO Biological Processes -13.9027363 39 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051591 response to cAMP GO Biological Processes -5.58721401 9 More
GO:0051604 protein maturation GO Biological Processes -20.0856790 31 More
GO:0051917 regulation of fibrinolysis GO Biological Processes -20.6622986 13 More
GO:0051918 negative regulation of fibrinolysis GO Biological Processes -14.1555780 9 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0061045 negative regulation of wound healing GO Biological Processes -28.2986689 25 More
GO:0090303 positive regulation of wound healing GO Biological Processes -15.9447313 16 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:1900046 regulation of hemostasis GO Biological Processes -39.0044157 31 More
GO:1900047 negative regulation of hemostasis GO Biological Processes -30.8008788 23 More
GO:1900048 positive regulation of hemostasis GO Biological Processes -18.9359595 14 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903035 negative regulation of response to wounding GO Biological Processes -27.3379640 26 More
GO:1903036 positive regulation of response to wounding GO Biological Processes -14.4451296 16 More
GO:1905286 serine-type peptidase complex GO Cellular Components -11.3739342 10 More
GO:1905368 peptidase complex GO Cellular Components -4.61293625 9 More
GO:1905369 endopeptidase complex GO Cellular Components -3.16416938 6 More
GO:1905370 serine-type endopeptidase complex GO Cellular Components -8.85311859 8 More
KEGG pathways: 3 records
KEGG Description Category LogP Number of genes Detail
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
hsa04933 AGE-RAGE signaling pathway in diabetic complications KEGG Pathway -25.8646207 26 More
hsa05418 Fluid shear stress and atherosclerosis KEGG Pathway -23.1665561 27 More
Drug-Gene interaction
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Related drugs: 5 records
Related studies: 11 records
Molecular factor Omics type Application Objective MI type Reference
NM_000361.3:c.1418C>T genomics myocardial infarction[diagnosis] myocardial infarction Norlund L et al. Thromb Haemost. 1997
NG_012027.1:g.4959G>A genomics acute myocardial infarction[diagnosis] acute myocardial infarction Li YH et al. Thromb Haemost. 2002
NG_012027.1:g.4959G>A genomics myocardial infarction[diagnosis] myocardial infarction Park HY et al. Hypertens Res. 2002
NG_012027.1:g.4959G>A genomics acute myocardial infarction[diagnosis] acute myocardial infarction Chao TH et al. Am J Cardiol. 2004
NM_000361.3:c.1418C>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Dogra R et al. Clin Appl Thromb Hemost. 2013
thrombomodulin proteomics thrombolytic agent[treatment (pharmacotherapy)] acute ST elevation myocardial infarction Ohlin AK et al. Thromb Res. 1996
thrombomodulin proteomics myocardial reperfusion[prognosis (good)] acute ST elevation myocardial infarction Ileri M et al. Clin Cardiol. 2001
thrombomodulin proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Liao XX et al. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008
thrombomodulin proteomics medium predictor acute kidney failure[prognosis (bad)] acute myocardial infarction Liu KL et al. Crit Care. 2014
thrombomodulin proteomics acute anterior ST elevation myocardial infarction[diagnosis] acute anterior ST elevation myocardial infarction Hojagergaard MA et al. Biomarkers. 2020
thrombomodulin proteomics poor predictor cardiogenic shock[prognosis (bad)] ST elevation myocardial infarction Frydland M et al. Shock. 2018
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